Objective: To investigate the effect of increasing enteral nutrition infusion rate on intra-abdominal pressure and early enteral nutrition in patients with severe acute pancreatitis. Methods: A total of 183 patients with severe acute pancreatitis who were treated with ICU in our hospital from January 2015 to December 2016 were selected. According to the incremental rate of enteral nutrition infusion, they were divided into a low-speed incremental group (62 cases), a medium-rate incremental group (61 cases), and a high-speed incremental group (60 cases). The intra-abdominal pressure changes in patients of three groups were compared, and the incidence of early enteral nutrition feeding intolerance was compared. Results: After enteral nutrition in patients, the intra-abdominal pressure of patients in the low-speed incremental group was significantly lower than that in the middle-increment group and the high-speed group. The incidence of bloating, diarrhea, vomiting/regurgitation, gastric retention, and gastrointestinal bleeding in the low-speed incremental group was significantly lower than that in the high-speed incremental group (P<0.05). The incidence of bloating in the low-speed incremental group was lower than that in the medium-speed incremental group (P<0.05). Patients in the high-speed incremental group had the first symptoms of bloating, and there was a statistically significant difference (P<0.05) compared with the time when abdominal distension occurred in the patients with moderate-increasing rate. Conclusion: When early enteral nutrition is administered through nasojejunal feeding tube in patients with severe acute pancreatitis, low-incremental infusion is beneficial to reduce intra-abdominal pressure, and there is less occurrence of feeding intolerance.