Objective: To study the clinicopathologic feature of chordoma. Methods: The clinical data of 52 cases of chordoma were retrospectively analyzed, including clinical features, pathological morphology, immunophenotype, treatment and prognosis. Results: The age ranged from 27–79 years (median age: 58 years), 29 males and 23 females were included. Forty-six cases occurred in the sacrococcygeal, 2 cases in the sella, 1 case in the slope, 2 cases in the cervical spine and 1 case in the lumbar spine. Radiology images showed the osteolytic destruction. Morphologically, the tumor cells were lobulated, rich in mucin-like matrix and had visible intracellular vesicles. Immunohistochemistry showed epithelial markers and S100 protein were positively expressed. One of these cases dedifferentiated into fibrosarcoma, with an increased Ki67 proliferation index. Among these cases, 27 (52%) recurred and 3 metastasized. Conclusion: Chordoma is more common in the axial bone of middle-aged and elderly people, with low degree of malignancy, common recurrence, and possibility of metastasis. The main pathological type is classical type, and sometimes it may occur dedifferentiation suggesting poor prognosis. Immunohistochemistry is contribute to diagnosis and differential diagnosis.