盆腔高级别浆液性腺癌1例并文献复习
| 作者: |
1张加鑫,
1赵颖华,
2刘相良,
1王权
1 吉林大学第一医院胃肠外科，长春 130021 2 吉林大学第一医院肿瘤中心，长春 130021 |
| 通讯: |
王权
Email: 297139732@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.04.036 |
摘要
患者，女，60岁，因乳腺和甲状腺肿物入院，行超声、穿刺活检后确诊为乳腺癌和甲状腺癌。随后行腹部CT、穿刺活检后，确诊为盆腔高级别浆液性腺癌。患者乳腺癌、甲状腺癌术后，行多西他赛/卡铂/曲妥珠单抗(docetaxel/carboplatin/herceptin，TCH)化学治疗。化学治疗过程中见盆腔肿物明显减小，期间行盆腔肿物+全子宫及双侧附件切除术+部分直肠切除术+大网膜切除术+阑尾切除术。化学治疗结束后，肿块未见复发，予办理出院。经对盆腔高级别浆液性腺癌发生机制和治疗方法进行分析，提示p53基因的胚系突变可能是患者多原发肿瘤的原因之一，同时多西他赛+顺铂对高级别浆液性腺癌具有较好疗效。
关键词：
高级别浆液性腺癌；乳腺癌；p53；多原发肿瘤
Pelvic high-grade serous adenocarcinoma: A case report and literature review
CorrespondingAuthor: WANG Quan Email: 297139732@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.04.036
Abstract
This article reports a case of pelvic high-grade serous adenocarcinoma. After line ultrasound and biopsy, patient confirmed as breast cancer and thyroid cancer. Followed by abdominal CT and biopsy, the diagnosis of pelvic high-grade serous adenocarcinoma was proved. Patient has TCH chemotherapy after breast cancer and thyroid cancer operation. The pelvic tumor was significantly reduced during chemotherapy. During chemotherapy, patient was having pelvic masses + hysterectomy and bilateral attachment resection + partial rectal resection + omental resection + appendectomy. After chemotherapy, tumor had no recurrence. This article discusses the mechanism and treatment of high-grade serous adenocarcinoma of the pelvic cavity. It is suggested that the germ-line mutation of p53 gene may be one of the reasons for multiple primary tumors in patients. Docetaxel and cisplatin have benefits on high-grade serous adenocarcinoma.
Keywords：
high-grade serous adenocarcinoma; breast cancer; p53; multiple primary tumor