内皮间质转化在心肌纤维化中的机制及应用
| 作者: |
1曲嘉琛,
1袁也,
1,2唐俊明,
1,3王家宁
1 湖北医药学院附属人民医院临床医学研究所，湖北 十堰 442000 2 湖北医药学院基础医学院生理学教研室，湖北 十堰 442000 3 湖北医药学院附属人民医院心脏中心，湖北 十堰 442000 |
| 通讯: |
王家宁
Email: rywjn@VIP.163.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.04.034 |
| 基金: | 国家自然科学基金(81270221，81670272)；湖北医药学院创新团队项目(FDFR201601)。 |
摘要
内皮间质转化(endothelial-mesenchymal transition，EndMT)是指在多项影响因素的作用下，内皮细胞的结构和功能向间质细胞转变。研究显示在内皮的功能调节、心肌细胞、血管及心脏瓣膜等的发育和结构重塑等方面都有EndMT参与，表明心血管疾病领域在该方面投入更多研究的意义逐渐凸显。了解EndMT过程中信号转导通路，有助于进一步认识EndMT引起心肌纤维化(myocardial fibrosis，MF)的机制，为探索干预MF的治疗方案提供更多依据。
关键词：
内皮间质转化；心肌纤维化；信号转导通路
Mechanisms of endothelial-mesenchymal transition induced myocardial fibrosis and its application
CorrespondingAuthor: WANG Jia’ning Email: rywjn@VIP.163.com
DOI: 10.3978/j.issn.2095-6959.2018.04.034
Foundation: This work was supported by the National Natural Science Foundation (81270221, 81670272) and Hubei University of Medicine Innovative Team Project (FDFR201601)
Abstract
Endothelial-mesenchymal transition (EndMT) results from the induction of some transcription factors, leading to a shift in cytoskeletal dynamics and a change of morphology and physiology from epithelial to the mesenchymal phenotype. Previous studies in recent years showed that EndMT participates in endothelial function regulation, development and remodeling of myocardial cells, vascular and heart valves, which indicates the essence of research on EndMT in cardiovascular diseases. Therefore, to understand the mechanisms and signal pathways of EndMT may provide therapeutic strategies and perspective for treating the diseases.
Keywords：
endothelial-mesenchymal transition; myocardial fibrosis; signal pathways