文章摘要

肺动脉高压中内皮间质转化信号通路的研究进展

作者: 1,2周选芬, 2,3戴爱国, 2胡瑞成, 2朱黎明, 2蒋永亮
1 南华大学研究生院，湖南 衡阳 421001
2 湖南省人民医院呼吸内科，长沙 410000
3 长沙医学院呼吸疾病研究所，长沙 410219
通讯: 戴爱国 Email: daiaiguo2003@163.com
DOI: 10.3978/j.issn.2095-6959.2018.04.032
基金: 国家自然科学基金(81270118，81570052，81370153)。

摘要

肺血管重塑是肺动脉高压(pulmonary arterial hypertension，PAH)主要的病理机制之一。内皮间质转化(endothelial to mesenchymal transition，EndMT)是肺血管重塑的重要病理基础。目前关于PAH机制的研究主要集中于血管细胞增殖，而涉及EndMT信号通路的研究并未深入。因此，探究肺动脉EndMT的信号机制并进行相应干预研究对治疗PAH起重要作用。
关键词： 肺动脉高压；肺血管重塑；内皮间质转化；信号通路

Research progress on the signal pathway of endothelial to mesenchymal transition in pulmonary arterial hypertension

Authors: 1,2ZHOU Xuanfen, 2,3DAI Aiguo, 2HU Ruicheng, 2ZHU Liming, 2JIANG Yongliang
1 Department of Graduate School, University of South China, Hengyang Hunan 421001, China
2 Department of Respiratory Medicine, Hunan Provincial People’s Hospital, Changsha 410000, China
3 Institute of Respiratory Diseases, Changsha Medical University, Changsha 410219, China

CorrespondingAuthor: DAI Aiguo Email: daiaiguo2003@163.com

DOI: 10.3978/j.issn.2095-6959.2018.04.032

Foundation: This work was supported by the National Natural Science Foundation of China (81270118, 81570052)

Abstract

Pulmonary vascular remodeling is the major pathological mechanism in pulmonary arterial hypertension (PAH), and endothelial to mesenchymal transition (EndMT) plays an important role of this process. Current researches about the molecular mechanisms of PAH mainly focus on cell proliferation, but the specific signal path of EndMT is still not clear. Therefore, an important strategy for the treatment of PAH is to explore the signal mechanism of EndMT in PAH with corresponding targeted intervention.
Keywords： pulmonary arterial hypertension; pulmonary vascular remodeling; endothelial to mesenchymal transition; signal pathway

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