鼻咽部低级别乳头状腺癌诊断与治疗的研究进展
| 作者: |
1吕蓓蓓,
1徐嘉雯,
1李加美,
2王宏量
1 山东大学附属省立医院病理科，济南 250021 2 山东省职业卫生与职业病防治研究院，山东省医学科学院，济南 250062 |
| 通讯: |
王宏量
Email: hlwang824@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.04.029 |
| 基金: | 国家自然科学基金青年科学基金(81202092)；山东省重点研发计划项目(2015GSF118015)。 |
摘要
鼻咽部低级别乳头状腺癌(low-grade nasopharyngeal papillary adenocarcinoma，LGNPPA)是发生在鼻咽部的十分罕见的以乳头状结构为主的低级别腺癌，其病因不明。镜下肿瘤细胞呈乳头状及腺样结构排列，免疫组织化学甲状腺转录因子-1(thyroid transcription factor-1，TTF-1；也称甲状腺特异增强子结合蛋白)呈弥漫强阳性表达，易与转移性乳头状癌等混淆，因其惰性的生物学行为，手术完整切除可治愈，预后良好。本文将对LGNPPA的临床病理表现、诊断与鉴别诊断、发病机制及对该病的最新诊治共识进行阐述，以提高对该病的认识。
关键词：
鼻咽部低级别乳头状腺癌；甲状腺转录因子-1；诊断；鉴别诊断；治疗
Research progress in the diagnosis and treatment of low-grade nasopharyngeal papillary adenocarcinoma
CorrespondingAuthor: WANG Hongliang Email: hlwang824@163.com
DOI: 10.3978/j.issn.2095-6959.2018.04.029
Foundation: This work was supported by the National Natural Science Foundation Youth Science Fund Project (81202092) and the Shandong Province Key Research and Development Projects (2015GSF118015), China.
Abstract
Low-grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is very rare low-grade adenocarcinoma occurring in the nasopharynx and the main manifestation is papillary structure. The etiology is unclear. Microscopic tumor cells manifest as papillary and adenoid-like structure. Immunohistochemically, thyroid transcription factor-1 (TTF-1) was diffusely strong positive, which makes it easily confused with metastatic papillary carcinoma. Because of its inert biological behavior, complete surgical resection can be cured and the prognosis is good. This article will review clinical and pathological findings, diagnosis and differential diagnosis, pathogenesis and the latest consensus on diagnosis and treatment of LGNPPA, in order to raise awareness of the disease.
Keywords：
low-grade nasopharyngeal papillary adenocarcinoma; thyroid transcription factor-1; diagnosis; differential diagnosis; treatment