Objective: To discuss the value of multidisciplinary pulmonary rehabilitation intervention to lung cancer patients with moderate and severe chronic obstructive pulmonary disease (COPD). Methods: A total of 64 lung cancer patients with moderate and severe COPD who accepted operation in our hospital from April 2015 to December 2016 were divided into a control group and an observation group randomly. Each group had 32 patients. The control group adopted routine preoperative management scheme; in contrast, the observation group received multidisciplinary pulmonary rehabilitation intervention, including 2 weeks of intensive exercise, breathing exercises and oral nutrition supplement intervention, postoperative reasonable analgesia, early respiratory function exercise, exercise and oral nutrition supplement. lung function indexes, serum nutritional indexes and postoperative related indexes were collected before and after intervention were collected and compared. Results: The first second forced expiratory volume of vital capacity ratio expected (FEV1%pre), the first second forced expiratory volume ratio of forced vital capacity (FEV1/FVC) and maximal voluntary ventilation (MVV) in the observation group were significantly better than those in the control group in the first days before operation. The serum albumin (ALB), prealbumin (PA), transferrin (TF) and fibronectin (FN)of the observation group were significantly better than the control group in the third days after operation. Moreover, average postoperative thoracic duct stay time and average hospital stay length of the observation group were shortened obviously; the occurrence rates of postoperative pulmonary atelectasis, pulmonary infection and respiratory failure were evidently lower than those of the control group. Conclusion: Multidisciplinary pulmonary rehabilitation intervention can effectively improve the pulmonary functional status of lung cancer patients with moderate and severe pulmonary ventilation function disorder, improve postoperative nutritional status, and reduce the occurrence rate of postoperative complications. Therefore, this method is worthy of being promoted in clinic.