文章摘要

细胞自噬与神经退行性疾病机制的研究进展

作者: 1冯会超, 2陈乃耀
1 华北理工大学研究生院，河北 唐山 063210
2 华北理工大学附属医院血液内科，河北 唐山 063000
通讯: 陈乃耀 Email: nychenncmc@163.com
DOI: 10.3978/j.issn.2095-6959.2018.03.033
基金: 2014年河北省政府资助临床医学优秀人才培养项目。

摘要

自噬是真核细胞特有的溶酶体途径降解细胞内代谢物的过程，其变化与阿尔茨海默病(Alzheimer’s disease，AD)、帕金森病(Parkinson’s disease，PD)等神经退行性疾病的发生发展有密切联系。调节自噬可有效清除神经系统中异常积聚的蛋白质，从细胞水平上缓解疾病进展。由此可见，自噬方向可能是一种治疗神经退行性疾病的有效策略和途径。
关键词： 细胞自噬；神经退变性疾病；α-突触蛋白；β-淀粉样蛋白

Advances in mechanisms of autophagy and neurodegenerative diseases

Authors: 1FENG Huichao, 2CHEN Naiyao
1 School of Graduate, North China University of Science and Technology, Tangshan Hebei 063210, China
2 Department of Hematology, Affiliated Hospital of North China University of Science and Technology, Tangshan Hebei 063000, China

CorrespondingAuthor: CHEN Naiyao Email: nychenncmc@163.com

DOI: 10.3978/j.issn.2095-6959.2018.03.033

Foundation: This work was supported by the Hebei Provincial Government Foundation of Excellent Talent Training Grogram for Clinical Medicine 2014, China.

Abstract

Autophagy is a unique process of lysosomal pathway of eukaryotic cells to degrade intracellular metabolites and autophagy dysfunction is closely related to neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s syndrome (PD). Regulating autophagy can effectively remove the protein from abnormal accumulation in the nervous system and alleviate the disease progression from the cellular level. Thus, autophagy may be an effective strategy and approach for treating neurodegenerative diseases.
Keywords： autophagy; neurodegenerative; α-synuclein; amyloid β-protein

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