树突状相关外泌体在肿瘤中的研究进展
| 作者: |
1冯奇,
1郭鹏,
1王东来,
2吕健,
1冯建刚
1 河北医科大学第四医院骨科，石家庄 050011 2 河北医科大学第四医院普外二科，石家庄 050011 |
| 通讯: |
冯建刚
Email: fengjiangang0311@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.03.032 |
| 基金: | 河北省青年科技课题(20170692)。 |
摘要
树突状细胞相关外泌体(DC-derived exosomes，Dex)是由免疫系统的前哨抗原提呈细胞形成的微小囊泡。Dex表面拥有与树突状细胞(dendritic cell，DCs)部分相同的表面分子，如功能性MHC-抗原肽复合物(MHC/antigenic peptide)、共刺激分子(costimulatory molecules)等，并参与机体免疫调节。近年来随着对Dex研究的不断深入，Dex在肿瘤免疫中的作用越来越受到重视。基于Dex抗肿瘤治疗的临床试验也显示其潜在的可行性。
关键词：
树突状相关外泌体；肿瘤免疫；免疫治疗
Research progress of DC-derived exosomes in tumors
CorrespondingAuthor: FENG Jiangang Email: fengjiangang0311@163.com
DOI: 10.3978/j.issn.2095-6959.2018.03.032
Foundation: This work was supported by Hebei Provincial Youth Science and Technology Project, China (20170692).
Abstract
DC-derived exosomes (Dex) are micro-membrane vesicles that are secreted by the sentinel antigen-presenting cells of the immune system dendritic cell (DCs). Similar like DCs, the molecular composition of Dex includes surface expression of functional MHC-peptide complexes, costimulatory molecules, etc. Recently, with the deepening research in Dex, more and more attention has been focused on the role of Dex in tumor immunity. Dex-based clinical trials have been conducted in anti-malignancies therapies, showing the potential feasibility of the approach.
Keywords：
DC-derived exosomes; tumor immunity; immunotherapy