甘露糖结合凝集素补体途径与糖尿病肾病的相关性的研究进展
| 作者: |
1陈春雷,
1刘晓刚,
2禹程远,
1梁慧,
3袁福才,
1解汝娟
1 哈尔滨医科大学附属第一医院肾内科，哈尔滨 150000 2 哈尔滨医科大学附属第一医院老年病科，哈尔滨 150000 3 哈尔滨医科大学附属第一医院心血管内科，哈尔滨 150000 |
| 通讯: |
解汝娟
Email: hljxrj@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.03.026 |
| 基金: | 国家自然科学基金(81670659)。 |
摘要
糖尿病肾病是糖尿病最严重的微血管并发症，是终末期肾病的重要病因之一。甘露糖结合凝集素(mannose-binding lectin，MBL)是糖尿病肾病发生发展重要的生物标志物，H型纤维胶原凝集素(H-ficolin)也与糖尿病肾病的发展有关，而MBL相关丝氨酸蛋白酶与糖尿病肾病的关系有待进一步研究。
关键词：
糖尿病肾病；甘露糖结合凝集素；H型纤维胶原凝集素；甘露糖结合凝集素相关丝氨酸蛋白酶
Research progress on the relationship between mannose binding lectin complement pathway and diabetic nephropathy
CorrespondingAuthor: XIE Rujuan Email: hljxrj@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.03.026
Foundation: This work was supported by the National Natural Science Foundation of China (81670659).
Abstract
Diabetic nephropathy is one of the most important microvascular complications of diabetes, and is a significant cause of end-stage renal disease. There is evidence that the mannose binding lectin (MBL) has become a common development biomarker of diabetic nephropathy, and H-ficolin is also associated with the development of diabetic nephropathy, but the relationship between MBL associated serine protease and diabetic nephropathy remains to be further studied.
Keywords：
diabetic nephropathy; mannose binding lectin; H-ficolin; mannose binding lectin associated serine protease