Objective: To investigate the clinical efficacy of “ocular iontophoresis + pulse + hypothermia” mode in the treatment of diabetic retinopathy. Methods: Sixty cases of patients with diabetic retinopathy from January 2016 to June 2017 in our hospital were randomly divided into intervention group and control group, the control group took the “guide” model of Salvia miltiorrhiza ocular iontophoresis treatment, the intervention group on the basis of the control group, adding pulse mode and temperature (low temperature) intervention, the visual acuity changes and clinical effects were compared between the two groups. Results: The total effective rate in the control group was 60% with 8 markedly effective cases, 10 effective cases and 12 ineffective cases, while the total effective rate in the intervention group was 90% with 12 markedly effective cases, 15 effective cases and 3 ineffective cases. The effective rate of the intervention group was significantly higher than that of the control group (P<0.05). Conclusion: The “ocular iontophoresis + pulse + hypothermia” mode can enhance the clinical effect and is worthy of further promotion in clinic.