Objective: To investigate the clinical application advantages of subcutaneous tunnel method for lumbar drainage in aneurysmal subarachnoid hemorrhage after craniotomy. Methods: In this prospective randomized control study, 80 aneurysmal subarachnoid hemorrhage after craniotomy form September 2015 to May 2017 were randomized to the study group of conventional therapy plus subcutaneous tunnel and the control group of conventional therapy alone. The study group and control group included 40 patients, respectively. The infection rate associated with lumbar drainage and puncture point leakage rate were evaluated. Results: Of the 40 patients in the study group, the leakage rate of puncture points was 0.0% (0/40), which was significantly lower than the control group of 12.5% (5/40), and the difference was statistically significant (P=0.021). The incidence rate of lumbar drainage-related infections were 7.5% (3/40) in the study group and 12.5% (5/40) in the control group, and the difference was not statistically significant (P=0.456), but there was a decrease in infection rate. Conclusion: Subcutaneous tunnel lumbar drainage in the aneurysmal subarachnoid hemorrhage after craniotomy can significantly reduce the puncture point leakage, the advantage of prevention of secondary drainage-related infections after lumbar catheterization is great and is worth popularizing in clinical practice.