血清肌肉生长抑制素及超敏C-反应蛋白与老年患者肌肉减少症的相关性
| 作者: |
1郑旭冬,
1康冬梅
1 安徽省立医院老年医学科，合肥 230001 |
| 通讯: |
郑旭冬
Email: 1325284178@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.03.010 |
| 基金: | 安徽省自然科学基金(1608085MH206)。 |
摘要
目的：测定老年骨骼肌肉减少症患者血清肌肉生长抑制素(myostatin，MSTN)、超敏C-反应蛋白(hypersensitive C-reactive protein，hs-CRP)的水平，探讨二者对老年患者肌肉减少症的临床意义。方法：收集肌肉减少症患者血清40例，对照组42例，测定两组血清MSTN，hs-CRP水平，并分析肌肉减少症组MSTN，hs-CRP的相关性。结果：肌肉减少症组血清MSTN，hs-CRP水平高于对照组，差异有统计学意义(P<0.001)。结论：血清MSTN，hs-CRP水平均为诊断肌肉减少症的较为敏感、准确、可靠的指标，在老年肌肉减少症患者的诊断、治疗、病情监测上有一定意义。
关键词：
肌肉生长抑制素；超敏C-反应蛋白；老年；肌肉减少症
Correlation of serum myostatin and hypersensitivity C-reactive protein with sarcopenia in elderly patients
CorrespondingAuthor: ZHENG Xudong Email: 1325284178@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.03.010
Foundation: This work was supported by Natural Science Foundation of Anhui Province, China (1608085MH206).
Abstract
Objective: To determine the level of serum myostatin (MSTN) and hypersensitivity C-reactive protein (hs-CRP) in patients with sarcopenia, and to explore the clinical significance of these two factors in elderly patients with sarcopenia. Methods: Serum samples from 40 patients with sarcopenia and 42 patients in the control group were collected. Serum levels of MSTN and hs-CRP were measured in two groups, and the correlation between MSTN and hs-CRP in sarcopenia group was analyzed. Results: Levels of serum MSTN and hs-CRP in the sarcopenia group were higher than those in the control group, and the difference was statistically significant (P<0.01). Conclusion: Levels of serum MSTN and hs-CRP are both sensitive and accurate indicators for the diagnosis of sarcopenia. Combined detection of them has certain significance in the diagnosis, treatment and disease monitoring of elderly patients with sarcopenia.
Keywords：
myostatin; hypersensitivity C-reactive protein; elderly patients; sarcopenia