文章摘要

妊娠糖尿病患者血钾水平与胰岛素抵抗的相关性

作者: 1杨志新
1 目的：探讨妊娠糖尿病(gestational diabetes mellitus，GDM)患者中血钾水平与胰岛素抵抗的相关性分析。方法：根据口服葡萄糖耐量试验(oral glucose tolerance test，OGTT)结果选取200例妊娠糖尿病患者，收集空腹血样本及糖负荷后0.5，1，2 h血样本，测定血脂、血糖、胰岛素及血钾水平等，计算并评价胰岛素抵抗指数(HOMA-IR、Matsuda指数)。结果：在妊娠糖尿病患者中，HOMA-IR与孕前BMI，TC，TG呈正相关，与血钾呈负相关；Matsuda指数与孕前BMI，TC，TG呈负相关，与血钾呈正相关。多元逐步回归分析提示，在校正孕前BMI、血脂等因素后，血钾水平仍然与HOMA-IR和Matsuda指数相关，说明血钾水平是胰岛素抵抗指数的独立影响因素。结论：在妊娠糖尿病患者中，血钾水平与胰岛素抵抗密切相关，可为预防和治疗妊娠糖尿病提供新方法。
通讯: 杨志新 Email: yzhxfuchan@126.com
DOI: 10.3978/j.issn.2095-6959.2018.03.009

摘要

目的：探讨妊娠糖尿病(gestational diabetes mellitus，GDM)患者中血钾水平与胰岛素抵抗的相关性分析。方法：根据口服葡萄糖耐量试验(oral glucose tolerance test，OGTT)结果选取200例妊娠糖尿病患者，收集空腹血样本及糖负荷后0.5，1，2 h血样本，测定血脂、血糖、胰岛素及血钾水平等，计算并评价胰岛素抵抗指数(HOMA-IR、Matsuda指数)。结果：在妊娠糖尿病患者中，HOMA-IR与孕前BMI，TC，TG呈正相关，与血钾呈负相关；Matsuda指数与孕前BMI，TC，TG呈负相关，与血钾呈正相关。多元逐步回归分析提示，在校正孕前BMI、血脂等因素后，血钾水平仍然与HOMA-IR和Matsuda指数相关，说明血钾水平是胰岛素抵抗指数的独立影响因素。结论：在妊娠糖尿病患者中，血钾水平与胰岛素抵抗密切相关，可为预防和治疗妊娠糖尿病提供新方法。
关键词： 血钾；胰岛素抵抗；妊娠糖尿病

Correlation between serum potassium and insulin resistance in patients with gestational diabetes mellitus

Authors: 1YANG Zhixin
1 Objective: To explore the correlation between serum potassium and insulin resistance in patients with gestational diabetes mellitus (GDM). Methods: A total of 200 GDM patients were enrolled in our study. All patients underwent a standard oral glucose tolerance test (OGTT). Their clinical, serum potassium and insulin were measured. Insulin secretion indices were measured by HOMA-IR and Matsuda index. Results: In GDM, HOMA-IR was postively correlated with progestation BMI, TC, TG and negatively correlated with serum potassium; Matsuda index was negatively correlated with progestation BMI, TC, TG and postively correlated with serum potassium. The multiple regression model analysis showed that serum potassium was closely correlated to HOMA-IR and Matsuda index independent of any factors. Conclusion: In GDM, serum potassium can influence insulin resistance which provides a new treatment strategy for preventing and therapy GDM.

CorrespondingAuthor: YANG Zhixin Email: yzhxfuchan@126.com

DOI: 10.3978/j.issn.2095-6959.2018.03.009

Abstract

Objective: To explore the correlation between serum potassium and insulin resistance in patients with gestational diabetes mellitus (GDM). Methods: A total of 200 GDM patients were enrolled in our study. All patients underwent a standard oral glucose tolerance test (OGTT). Their clinical, serum potassium and insulin were measured. Insulin secretion indices were measured by HOMA-IR and Matsuda index. Results: In GDM, HOMA-IR was postively correlated with progestation BMI, TC, TG and negatively correlated with serum potassium; Matsuda index was negatively correlated with progestation BMI, TC, TG and postively correlated with serum potassium. The multiple regression model analysis showed that serum potassium was closely correlated to HOMA-IR and Matsuda index independent of any factors. Conclusion: In GDM, serum potassium can influence insulin resistance which provides a new treatment strategy for preventing and therapy GDM.
Keywords： serum potassium; insulin resistance; gestational diabetes mellitus

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