大炎肽/同种异体移植排斥反应因子1的研究进展
| 作者: |
1于雅丽,
1郝丽荣
1 哈尔滨医科大学附属第一医院肾内科，哈尔滨 150000 |
| 通讯: |
郝丽荣
Email: Hao_lirong@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.02.034 |
| 基金: | 国家自然科学基金(81570638)。 |
摘要
大炎肽(Daintain)/同种异体移植排斥反应因子1(allograft inflammatory factor 1，AIF-1)分布于猪小肠、同种异体心脏移植鼠体内、自身免疫性脑脊髓炎病灶部位、糖尿病前期BB鼠胰腺及远古海洋类物质(如海绵)、腺皮层和淋巴结的树突细胞、胚胎、脾、肺、睾丸及乳腺癌、胃癌病灶等，能促进巨噬细胞活化、血管平滑肌细胞增殖和迁移等，在多种疾病中起重要作用。
关键词：
移植排斥反应；自身免疫性疾病；肿瘤；血管性疾病
Research progress in Daintain/allograft inflammatory factor 1
CorrespondingAuthor: HAO Lirong Email: Hao_lirong@163.com
DOI: 10.3978/j.issn.2095-6959.2018.02.034
Foundation: This work was supported by the National Natural Science Foundation of China (81570638).
Abstract
Daintain/allograft inflammatory factor 1 (AIF-1) was found in the porcine intestine and allograft heart transplant rejection mice. The following study shows that it was distributed in the allograft heart transplant rejection mice, autoimmune encephalomyelitis lesions, pre-diabetic pancreas of the BB rats, and ancient marine species such as the sponge, glandular cortex, and the Dendritic cells of lymphnodes, embryos, spleens, lungs and testa, mammary gland carcinomas, gastric carcinomas. It can promote macrophage activation, vascular smooth muscle cell proliferation and migration, playing an important role in a variety of diseases. This article provides an overview of recent research conducted by Daintain/AIF-1.
Keywords：
graft rejection; autoimmune disease; tumor; vascular disease