Objective: To investigate and understand the status of health information literacy in patients with coronary heart disease (CHD), to analyze the impact of health information literacy on the search behavior of network health knowledge, and to provide clinical basis for promoting the health guidance of patients with CHD. Methods: Cross-sectional survey was applied. Patients with CHD hospitalized in our hospital from January to June of 2016 were selected as the research objects. Then the patients were investigated by the use of questionnaire and computer experiment. We divided the patients into observation group and control group based on whether the patients have health information literacy and compared the search behavior of network health information in both groups. Results: One hundred and twenty-six (96.92%) valid data were received, in which 59 patients (46.82%) with CHD had health information literacy; the most commonly used search tool for them was search engine, and the proportion selecting the search engine in the observation group was significantly lower than that in the control group (P<0.05), and the proportion selecting the healthy website was also sharply higher (P<0.05). The selection length and retrieval time of the observation group were significantly lower than those of the control group (P<0.05) and the proportion difference in the retrieval component was statistically significant (P<0.05). The number of browsing websites and browsing time of observation group were (6.81±4.01) and (3.47±1.69) min, which were significantly higher than those of control group (4.33±2.64) and (2.62±1.30) min. And the proportion difference in the action component of websites browse was statistically significant (P<0.05); the most frequently selected information source for patients with CHD was comprehensive quiz website; the health information websites in the observation group was much profounder than those in the control group (P<0.05) and the proportion selecting the advertising sites was significantly lower than that in the control group (P<0.05). Conclusion: Favorable health information literacy is helpful to the selection of professional search tools for young and middle-aged patients with CHD. It can retrieve quickly and accurately and improve the details and precision obviously, so as to achieve more professional health information.