Objective: To investigate the expectation of medical staffs working in osteoporosis-related fields on possible competency of osteoporosis specialized nurses (OP SNs), and further guide the modification of constructed competency model of OP SNs and construction of core competency evaluation index system for OP SNs. Methods: A self-developed questionnaire named expectation of medical staffs on core competency of OP SNs was used, and then the multi-dimensional scaling (MDS) statistical method was adopted to perform data analysis. Results: Medial staffs selected the potential core competency for OP SNs based on the clinical function and level of expertise mainly. Nine specified core competencies including capacity of direct clinical practice, capacity of education and assistant, management capacity, capacity of guide and consultant, research capacity, empathy capacity, capacity of individual development, capacity of critical thinking, and capacity of ethical decision-making were identified. Of these nine core competencies, capacity of direct clinical practice, capacity of education and assistant, and capacity of ethical decision-making have utmost clinical function; whereas research capacity, capacity of ethical decision-making, and capacity of individual development were developed based on so high level of expertise. Conclusion: The development of the research capacity, capacity of individual development, capacity of education and assistant, and capacity of ethical decision-making should be emphasized according to the principles of clinical function and level of expertise when constructing the OP SNs staff.