Objective: To investigate the treatment effect of breast abscess during lactation on the basis of 14G indwelling needle puncture drainage combined with mammary dredge. Methods: Patients with lactating breast abscess in Guangzhou Women’s and Children’s Medical Center Breast Department. From July 2010 to July 2013, 181 people were in the control group, using conventional incision and drainage treatment; From August 2013 to August 2016, 185 were set up as observation groups, using 14G indwelling needle puncture drainage combined with breast dredging treatment. Results: The pain VAS scores of the observation group at the time of surgery, second days after surgery were significantly lower than the control group, Fgroup, Ftime and Finteraction in repeated measures ANOVA were statistically significant (P<0.001). The number of dressing changed and cured time of the observation group were significantly lower than the control group (P<0.001). Complications incidence and feeding stopping ratio of the observation group were 4.3% and 33.5%, was significantly lower than the control group 18.2% and 64.6%. Wound cosmetic satisfaction in the observation group was 83.2%, and significantly higher than 40.3% in the control group (P<0.001). Conclusion: 14G indwelling needle puncture drainage combined with breast dredge therapy is an effective strategy. The treatment can effectively reduce the pain, decrease the numbers of dressing changed, shorten the wound healing and hospitalization time.