甲状腺透明变梁状肿瘤2例临床病理分析及文献复习
| 作者: |
1陈小华
1 宜宾市第二人民医院病理科，四川 宜宾 644000 |
| 通讯: |
陈小华
Email: bran69@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.01.035 |
摘要
对2例甲状腺透明变梁状肿瘤(hyalinizing trabecular tumor，HTT)患者进行超声、术中冰冻病理切片、术后石蜡病理切片、免疫组织化学检测，分析患者的病理特征，并复习相关文献。2例HTT患者行超声检查可见肿瘤边界清楚，不均匀稍低回声团或回声结节，均行甲状腺占位病变组织切除术治疗，术中冰冻切片病理检查可见包膜完整、边界清楚，细胞呈卵圆形、短棱形，呈器官样排列，胞浆嗜酸，与术后石蜡切片检查结果相同。免疫组织化学检测显示2例HTT患者的甲状腺转录因子1(thyroid transcription factor 1，TTF-1)，CD56，甲状腺球蛋白(thyroglobulin，Tg)，Ki-67，半乳糖凝集素3(galectin-3)呈阳性，其余如角蛋白19(cytokeratin 19，CK19)，癌胚抗原(carcinoembryonic antigen，CEA)，嗜铬素(chromogranin A，CgA)，突触素(synaptophysin，Syn)，降钙素(calcitonin，CT)，人骨髓内皮细胞1(human bone marrow endothelial cell-1，HBME-1)等指标均阴性。可通过免疫组织化学方法检测上述指标将HTT与甲状腺乳头状癌(papillary thyroid carcinoma，PTC)、甲状腺髓样癌(medullary thyroid carcinoma，MTC)、甲状腺副神经节瘤(thyroid paraganglioma，TP)等类似肿瘤进行鉴别诊断。
关键词：
甲状腺；透明变梁状肿瘤；髓样癌；乳头状癌；病理分析
Hyalinizing trabecular tumor: Report of 2 cases and review of literature
CorrespondingAuthor: CHEN Xiaohua Email: bran69@126.com
DOI: 10.3978/j.issn.2095-6959.2018.01.035
Abstract
We retrospectively analyzed two patients with hyalinizing trabecular tumor (HTT), who underwent ultrasonography and reviewed relevant literature. Two HTT patients showed a clear tumor border, uneven hypoechoic echogenic mass or echo nodules during thyroidectomy lesions removal surgery. Intraoperative frozen section pathological examination showed complete capsule, with the clear boundary. The cells were oval, short prism, with organ-like arrangement, cytoplasmic acidosis. Immunohistochemical results showed that thyroid transcription factor 1 (TTF-1), CD56, thyroglobulin (Tg), Ki-67 and galectin-3 were positive in 2 patients with HTT, while cytokeratin 19 (CK19), carcinoembryonic antigen (CEA), chromogranin A (CgA), synaptophysin (Syn), calcitonin (CT), and human bone marrow endothelial cell-1 (HBME-1) were negative. Immunohistochemical detection of the above indicators can differentiate HTT from papillary thyroid carcinoma (PTC), medullary thyroid carcinoma (MTC), thyroid paraganglioma (TP) and other similar tumors.
Keywords：
thyroid; hyaline trabecular tumor; medullary carcinoma; papillary carcinoma; pathological analysis