富亮氨酸胶质瘤失活1蛋白抗体相关脑炎的研究进展
| 作者: |
1李维帅,
1郑东明
1 中国医科大学附属盛京医院神经内科，沈阳 110000 |
| 通讯: |
郑东明
Email: zhengdm@sj-hospital.org |
| DOI: | 10.3978/j.issn.2095-6959.2018.01.033 |
摘要
富亮氨酸胶质瘤失活1(leucine-rich glioma inactivated 1，LGi1)蛋白抗体相关脑炎是一种由LGi1抗体参与致病的新型自身免疫性脑炎，主要表现为认知障碍、癫痫、面臂肌张力障碍发作(faciobrachial dystonic seizure，FBDS)和顽固性低钠，其中FBDS是其特征性表现。与传统副肿瘤性自身免疫性脑炎不同，该病因其很少伴有肿瘤，经免疫调节治疗后可获得较好的预后。
关键词：
富亮氨酸胶质瘤失活1蛋白；面臂肌张力障碍发作；顽固性低钠；治疗；预后
Research progress in leucine-rich glioma inactivated 1 protein antibody-associated encephalitis
CorrespondingAuthor: ZHENG Dongming Email: zhengdm@sj-hospital.org
DOI: 10.3978/j.issn.2095-6959.2018.01.033
Abstract
Leucine-rich glioma inactivated 1 (LGi1) protein antibody-associated encephalitis is a new type of autoimmune encephalitis, characterized by cognitive impairment and epilepsy and faciobrachial dystonic seizures (FBDS) and intractable hyponatremia. Unlike traditional adenomatous autoimmune encephalitis, it is usually not tumour-associated, and its prognosis is better after immunomodulatory therapy.
Keywords：
leucine-rich glioma inactivated 1 protein; faciobrachial dystonic seizures; intractable hyponatremia; treatment; prognosis