胎盘生长因子在血液疾病研究中的新动向
| 作者: |
1张祝,
1高开波
1 三峡大学人民医院，宜昌市第一人民医院血液科，湖北 宜昌 443000 |
| 通讯: |
高开波
Email: 1010844690@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.01.032 |
摘要
胎盘生长因子(placental growth factor，PLGF)是一种由胎盘滋养层细胞和脐静脉内皮细胞产生的血管生成因子，广泛表达于缺血或受损的组织中，在肿瘤的发生与转移及炎性病理演变中发挥重要作用。最新的研究表明，PLGF是血红蛋白病、白血病、淋巴瘤等相关血液疾病的重要因子。本文结合国内外研究现状，分析PLGF在血液系统疾病中的临床意义与价值，旨在为血液系统疾病发病机制的研究与临床治疗药物的研发道明新方向。
关键词：
胎盘生长因子；镰状细胞病；白血病；造血干细胞移植；移植物抗宿主病；皮肤T细胞淋巴瘤
Research progress of the placental growth factor in blood system diseases
CorrespondingAuthor: GAO Kaibo Email: 1010844690@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.01.032
Abstract
Placenta growth factor (PLGF) is a kind of factor that produced by placental trophoblast cells and umbilical vein endothelial cells. It can be widely expressed in ischemic or damaged tissues and play an important role in tumor and inflammatory evolution. Recent studies have shown that PLGF is an important factor in hemoglobinopathy, leukemia, lymphoma and other blood diseases. In this paper, the clinical significance and value of PLGF in hematological diseases were analyzed, which aims to establish the new target for the study of the pathogenesis of hematological diseases and the development of clinical therapeutic drugs.
Keywords：
placental growth factor; sickle cell disease; leukemia; hematopoietic cell transplantation; graft versus host disease; cutaneous T-cell lymphoma