LIM kinase family includes two members: LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2), activated by the upstream signal molecules, and plays an important role in a variety of biological activities with a unique signal pathway. LIMK1 is a serine/threonine protein kinase, of which the physiological function is mainly to phosphorylate Cofilin to an inactivated pCofilin, and then participates in the regulation of cell actin skeleton polymerization, thereby regulates cell morphology, movement, adhesion and migration. There are a variety of mechanisms to regulate the activation of LIMK1. Activation of LIMK1 in the development of prostate cancer plays a vital role in the development process. Recent studies have shown that LIMK1 plays an important regulatory role in the migration and aggressiveness of prostate cancer cells, which may be the key molecules that cause invasion and metastasis of prostate cancer cell.