文章摘要

microRNA与口腔鳞状细胞癌的研究新进展

作者: 1汤伟伟, 2祝常青, 1何永文
1 昆明医科大学附属口腔医院口腔颌面外科，昆明 650031
2 昆明医科大学基础医学院病理教研室，昆明 650000
通讯: 何永文 Email: heyongwen2@sina.com
DOI: 10.3978/j.issn.2095-6959.2018.01.026
基金: 国家自然科学基金(81660448，81360401)，云南省高层次卫生技术人才培养专项经费(L-201612)，云南省应用基础研究计划项目(2017FE468-006)。

摘要

microRNA即miRNA，又被称为微小RNA，是一组由18~24个核苷酸长度组成的内源性非编码单链RNA，研究发现miRNA在包括口腔鳞状细胞癌在内的恶性肿瘤的发生发展中起重要的调控作用。以miRNA为靶标的靶向治疗受到人们的关注，针对miRNA的研究或许能为口腔鳞状细胞癌的治疗找到新的策略。
关键词： microRNA；口腔鳞状细胞癌；诊断靶向治疗

Recent advances in the research of microRNA in oral squamous cell carcinoma

Authors: 1TANG Weiwei, 2ZHU Changqing, 1HE Yongwen
1 Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Kunming Medical University, Kunming 650031, China
2 Department of Pathology, School of Basic Medical Sciences, Kunming Medical University, Kunming 650000, China

CorrespondingAuthor: HE Yongwen Email: heyongwen2@sina.com

DOI: 10.3978/j.issn.2095-6959.2018.01.026

Foundation: This work was supported by the National Natural Science Foundation (81360401, 81660448)

Abstract

MicroRNA or miRNA, is a group of which endogenous non-single stranded RNA composed of 18–24 nucleotides in length. miRNA was found in malignant tumors plays an important role in the development of oral squamous cell carcinoma. MiRNAs have been focused on targeted therapy. Studying on miRNA may find a new strategy for the treatment of oral squamous cell carcinoma. The roles of miRNA in the new research progress of OSCC development and the effect of diagnosis and treatment are reviewed.
Keywords： microRNA; oral squamous cell carcinoma; diagnosis targeted therapy

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