Acute glomerulonephritis can be referred to as acute nephritis. It is common in children, unusual in adults, seldom accompanied by nephrotic syndrome. Sporadic cases of acute nephritis associated with nephrotic syndrome have been reported both in China and abroad. It is rare that acute nephritis (or endocapillary proliferative glomerulonephritis) induced nephrotic syndrome with acute kidney injury, and only 3 cases reported in abroad, no clear reports in domestic. Steroids are not commonly used in acute glomerulonephritis, while the use of steroids in nephrotic syndrome remains controversial. We reported 1 case of renal biopsy con rmed endocapillary proliferative glomerulonephritis patients with acute nephritis, rarely manifested by nephrotic syndrome and acute kidney injury, and the disease was under control a er short term antibiotics and half-year steroid treatment.