With the aging of the society, the number of end-stage renal disease in elderly patients has increased gradually. Renal replacement therapy is the most important method for the treatment of end-stage renal disease. Among them, blood puri cation has become the most important renal replacement therapy for end-stage renal disease. However, elderly patients with end-stage renal disease are o en comitant with age-related multiple organ diseases, which are prone to various complications, even to death, and seriously a ect the life quality and clinical prognosis of elderly patients. Therefore, the improvement of therapeutic efficacy of end-stage renal disease, especially in elderly patients, is the key problem in the prevention and treatment of chronic kidney disease in China.