PDGF-BB/PDGFR-β 与肿瘤发生发展的研究进展
| 作者: |
1汤伟伟,
1何永文
1 昆明医科大学附属口腔医院口腔颌面外科，昆明 650031 |
| 通讯: |
何永文
Email: heyongwen2@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2017.11.028 |
摘要
血小板衍生生长因子(platelet-derived growth factor，PDGF)是一类重要的促血管生成因子，是 多种细胞的促有丝分裂剂和趋化因子，血小板衍生生长因子受体(platelet-derived growth factor receptor，PDGFR)是络氨酸蛋白激酶家族成员，能促进细胞的趋化增殖，PDGF和PDGFR在肿瘤 发生发展中起着重要作用，以PDGF/PDGFR为靶点作为肿瘤靶向治疗的研究也有了较大的进展。
关键词：
PDGF-BB/PDGFR-β
肿瘤
靶向治疗
Research progress of PDGF-BB/PDGFR-β in tumor
CorrespondingAuthor: He Yongwen Email: heyongwen2@sina.com
DOI: 10.3978/j.issn.2095-6959.2017.11.028
Abstract
Platelet-derived growth factor (PDGF) is a kind of angiogenic factor, is a variety of cell mitogenic agents and chemokines, platelet-derived growth factor receptor (PDGFR) is a member of the lysine protein kinase, which can promote the chemotaxis of cells. PDGF and PDGFR play an important role in the development of tumor. e study of PDGF/PDGFR as a target for tumor therapy has also made great progress. In this paper, review the progress of PDGF-BB/PDGFR-β in the development of tumor and the progress of tumor targeting therapy.
Keywords：
PDGF-BB/PDGFR-β
tumor
targeted therapy