Objective: To investigate the effects of virtual reality alliance frequency combined with repetitive transcranial magnetic stimulation (rTMS) on the upper limb dysfunction a er stroke. Methods: Forty-two patients su ering from upper limb dysfunction were randomly divided into a study group and a control group, 21 patients in each group. Both groups were given routine rehabilitation and virtual reality therapy, the patients in the study group were augmented frequency rTMS. The scores of Brunnstrom staging, simple Fugl-Meyer Assessment (FMA), modified Barthel index (MBI) and simple test for evaluating hand function (STEF) before and 4 weeks after the treatment were used to evaluate the upper limb movement function recovery. Results: After treatment for 4 weeks, the score of the Brunnstrom staging was 4.19±0.75 in the study group, and 3.29±0.71 in the control group; the score of FMA was 51.10±8.24 in the study group, and 37.14±7.88 in the control group; the score of MBI was 63.10±6.01 in the study group, and 49.76±7.49 in the control group; the score of STEF was 66.62±7.34 in the study group, and 54.90±9.63 in the control group, the differences were all statistically significant when compared with before treatment (P<0.05). The scores were significantly higher in the study group than those in the control group (P<0.05). Conclusion: On the basis of conventional treatment, virtual reality technology combined with rTMS can improve the function of upper limb movement in patients with hemiplegia of cerebral apoplexy and the quality of daily life of patients, which is worthy of clinical promotion.