Objective: To compare the effectiveness of the lateral anatomic locking plate and bilateral plates (lateral anatomic locking plate combined with the medial reconstructive plate) in the treatment of comminuted distal femoral fractures. Methods: Fifty-three patients with distal femoral comminuted fractures were treated with single or double plates and followed. There were 29 male and 24 female patients, aged from 23 to 67 (43.86± 10.40) years old, 34 cases of type 33-C2 and 19 cases of type 33-C3. There were 23 cases in the lateral plate group, including 13 males, 10 females, 14 of type C2 and 9 of type C3. ere were 30 cases in the bilateral plates group, including 16 males, 14 females, 20 of type C2, and 10 of type C3. A retrospective study was performed to compare the outcomes of two methods regarding operative time, perioperative blood loss, fracture union time, knee function evaluation score and complications. Results: Fi y-three patients were followed with 15.11± 1.68 months (12 to 17.5 months). There were significant differences between the two groups in perioperative blood loss, the operative time, assay of knee joint motion and the American Knee Society Score (AKS) knee functional score (P<0.05). e complication formation rate was 13%. However, the fracture healing time had no signi cant di erences (P>0.05). Conclusion: In treatment of the distal femur fracture, the double plate xation have be er joint function and more remarkable the operation e ect than the single plate method.