文章摘要

维生素D与糖尿病足病相关性的Meta分析

作者: 1王魁向, 2张健, 3马丁玲, 3谭喜庆, 2石振峰, 1孟利斌, 1郑磊, 2梁芳
1 河北医科大学附属邢台市人民医院关节骨科，河北 邢台 054000
2 河北医科大学附属邢台市人民医院内分泌科，河北 邢台 054000
3 中南大学湘雅三医院内分泌科，长沙 410013
通讯: 梁芳 Email: liangfang1024@sina.com
DOI: 10.3978/j.issn.2095-6959.2017.10.025

摘要

目的：探讨维生素D与糖尿病足病相关性。方法：检索关于维生素D与糖尿病足病相关参量影响的文献。纳入糖尿患者群(糖尿病组)及糖尿病足患者群(糖尿病足病组)为研究对象，以维生素D缺乏的发生率及25羟维生素D水平为研究指标的病例对照研究。采用Review Manager5.2软件对主要数据进行合并分析。对于计数资料(维生素D缺乏发生率)采用相对危险度(Odds ratio，OR)描述；对于计量资料(25羟维生素D水平)采用加权均数差(weighted mean difference，WMD)描述。结果：DF组维生素D缺乏的发生率高于糖尿病组，差异具有统计学意义(OR=1.81，95%CI 1.30~2.52，P<0.01)。DF组维生素D严重缺乏的发生率明显高于糖尿病组(OR=3.66，95%CI 2.56~5.25，P<0.01)。DF组维生素D水平较糖尿病组降低5.14 nmol/L(95%CI −7.31~−2.97，P<0.001)。结论：维生素D缺乏有可能是糖尿病足病发生的危险因素。
关键词： 糖尿病足病 维生素D meta分析

A Meta-analysis of correlation between vitamin D and diabetic foot

Authors: 1WANG Kuixiang, 2ZHANG Jian, 3MA Dingling, 3TANG Xiqing, 2SHI Zhenfeng, 1MENG Libin, 1ZHENG Lei, 2LIANG Fang
1 Department of Joint Orthopedics, Xingtai People’s Hospital, Hebei Medical University, Xingtai Hebei 054000
2 Department of Endocrinology, Xingtai People’s Hospital, Hebei Medical University, Xingtai Hebei 054000
3 Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China

CorrespondingAuthor: LIANG Fang Email: liangfang1024@sina.com

DOI: 10.3978/j.issn.2095-6959.2017.10.025

Abstract

Objective: To investigate the correlation between diabetic foot disease and vitamin D. Methods: The studies published about parameters of 25-hydroxy vitamin D related to diabetic foot were searched. The patients were divided into a diabetic foot group and a diabetes mellitus group. The incidence of vitamin D deficiency and 25-hydroxyl vitamin D levels were the main research indicators of case-control study. Review Manager5.2 software was used to conduct the statistical analysis. For count data (the incidence of vitamin D deficiency) using Odds ratio, description; For measurement data (vitamin D levels) using the weighted mean differences description. Results: The incidence of vitamin D deficiency in the diabetic foot group was higher than that of the diabetes mellitus group, the difference was statistically significant (OR =1.81, 95% CI 1.30–2.52, P<0.01). The incidence of severe lack of vitamin D in the diabetic foot group were significantly higher than that in the diabetes mellitus group (OR=3.66, 95% CI 2.56–2.56, P<0.01). The vitamin D levels in the diabetic foot group were significantly lower than that in the diabetes mellitus group (MD =−5.14 nmol/L, 95% CI −7.31– −2.97), P<0.001). Conclusion: Vitamin D deficiency is likely to be a risk factor for diabetic foot disease occurs.
Keywords： diabetic foot vitamin D meta-analysis

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