Objective: To compare the Clinical efficacy of vacuum sealing drainage (VSD) and traditional pressure dressing technology respectively combining with skin in situ replantation for the treatment of skin degloving injury of forearm. Methods: From Jan. 2003 to Jan. 2017, 90 patients of the degloving injury of forearm were treated by the method of VSD and traditional pressure dressing technology respectively combining with skin in situ replantation. There were 48 male and 32 females, aged 16–71 years (mean 38 years). Twelve cases were caused by traffic accidents, 68 cases by machine injuries. The study group included 40 patients who underwent VSD combining with skin in situ replantation operation, the other 40 patients accepted traditional pressure dressing technology combining with skin in situ replantation operation were the control group. The survival rate of skin graft, the length of hospital stay, the time of operation, the reoperation rate, the number of dressing change, the rate of wound infection and subcutaneous hematoma were compared between the two groups. Results: After the one-stage operation, the survival rate of skin of study group is 89.0%±9.2% and the control group is 72.6%±16.0%; the hospitalization time and the number of dressing change of study group were significantly shorter than those of the control group, the differences were all statistically significant (P<0.05). The reoperation rate and the rate of wound infection and subcutaneous hematoma of study group were lower than that in the control group, the differences were all statistically significant (P<0.05). Conclusion: The one-stage operation that uses skin in situ replantation combining with VSD technical to repair the degloving injury of forearm comparing to pressure dressing method can increase the survival rate of skin graft and reduce the incidence of wound infection and subcutaneous hematoma . This method could reduce the reoperation rate and it also could reduce the hospitalization time and the number of dressing change.