Objective: To investigate the effect of comprehensive nursing in the treatment of Alzheimer’s disease by oxiracetam for improving the neurological function and memory function. Methods: Eighty-six Alzheimer’s disease patients with dementia from May 2013 to January 2017 in Second Affiliated Hospital of Harbin Medical University were selected as the research object. According to the nursing method, the patients were divided into a control group (May 2013 to May 2015) and an intervention group (June 2015 to January 2017) according to the time of admission with 43 cases in each group. All patients were given with conventional symptomatic treatment combined with oxiracetam drugs. The control group of patients were given with routine clinical care and the intervention group of patients with comprehensive nursing mode with 2-week intervention. The neurological function, memory function, quality of life and depression after the intervention, and the patients or family satisfaction with nursing were compared between two groups. Results: After the intervention, the National Institute of Health stroke scale (NIHSS) score of the two groups were significantly decreased compared with before intervention, the scores of Wechsler Memory Scale-Revised (WMS-R) increased significantly (P<0.05), but those in two groups after the intervention had no significant difference (P>0.05); after the intervention, the Activity of Daily Living Scale (ADL) and Hamilton Anxiety Scale (HAMA) scores were lower than that in before intervention in two groups. The decreased degree of intervention group were significantly higher than that of control group, the difference was statistically significant (P<0.05); the nursing satisfaction between the intervention group and the control group were significantly different (97.67% vs 83.72%, P<0.05). Conclusion: Comprehensive nursing can significantly improve the quality of life and reduce the degree of depression in the treatment of Alzheimer's disease patients with dementia by oxiracetam, and easier to be accepted by the patients and their families, which can be used as the preferred mode of clinical nursing on patients with dementia.