Objective: To explore the therapeutic effect of home noninvasive positive pressure ventilation in patients with chronic left heart failure. Methods: We selected 51 patients with chronic left heart failure who were admitted to our hospital from January 2016 to December 2016. Patients were divided into a control group and a treatment group according to whether they agreed to use the ventilator. The control group was given conventional anti heart failure treatment. The treatment group was treated with conventional anti heart failure and non-invasive positive pressure ventilation. After 1-year treatment, the clinical symptoms, arterial partial pressure of oxygen (PaO2), the 6-minute walking test (6MWT), the level of brain natriuretic peptide (BNP) and left ventricular ejection fraction (LVEF) were observed. Results: After 1-year of treatment, the clinical symptoms, PaO2, 6MWT, BNP and LVEF improved significantly in the treatment group, which were significantly better than that in the control group (P<0.05). Conclusion: Home noninvasive positive pressure ventilation can improve the heart function of patients with chronic left heart failure, maintain the stability of heart function and improve the quality of life of patients.