Objective: To investigate the present situation of disease stigma, social function and self-efficacy in rectal cancer patients with permanent colostomy, and to analysis the correlation between disease stigma, social function and self-efficacy. Methods: By a convenient sampling, the 118 cases of rectal cancer patients with permanent colostomy were selected in our hospital from June 2015 to December 2016. Used Social Impact Scale (SIS), Social Support Rating Scale (SSRS) and stoma related self-efficacy questionnaire to survey patients with stigma, social support and self-efficacy, and analyzed the correlation between disease stigma, social function and self-efficacy with Spearman correlative test. Results: The score of disease stigma in rectal cancer patients with permanent colostomy was 59.47±11.03, the total score of social function was 43.11±5.85, and 55.08% of the patients had moderate self-efficacy. The score of disease stigma were negatively correlated with the scores of subjective support, objective support and social utilization in social support, and negatively correlated with the score of self-efficacy. Conclusion: The rectal cancer patients with permanent colostomy have a strong disease stigma, clinical nursing workers should take all-round measures to improve the level of social support in the patients to reduce the disease stigma, and improve the self-efficacy.