文章摘要

血清癌胚抗原、糖链抗原153与异常糖链糖蛋白在乳腺癌诊断中的应用

作者: 1祁洁, 2邹士涛, 2李晓庆
1 南京医科大学附属苏州医院甲状腺乳腺外科，江苏 苏州 215001
2 南京医科大学附属苏州医院肿瘤诊疗中心实验室，江苏 苏州 215001
通讯: 李晓庆 Email: lxqzyc@yeah.net
DOI: 10.3978/j.issn.2095-6959.2017.06.023
基金: 苏州市科技局应用基础研究计划, SYS201571

摘要

目的：探讨肿瘤异常糖链糖蛋白(tumor abnormal protein，TAP)、癌胚抗原(carcinoembryonic antigen，CEA)与糖链抗原153(carbohydrate antigen 153，CA153)在乳腺癌早期诊断中的临床价值。方法：收集45例乳腺癌患者为研究组，49例正常体检人群为对照组，比较各肿瘤志记物的敏感度、特异度、准确度等指标。结果：在乳腺癌组患者中，TAP，CEA，CA153检测敏感度分别为80.00%，8.89%，6.67%；特异度分别为100.00%，97.96%，100.00%，准确度分别为90.42%，55.32%，55.32%。结论：肿瘤TAP检测优于肿瘤标志物CEA和CA153检测，可作为乳腺癌的早期筛查指标。
关键词： 异常糖链糖蛋白 癌胚抗原 糖链抗原153 早期诊断 乳腺癌

Application of carcinoembryonic antigen, carbohydrate antigen 153 and tumor abnormal protein in the diagnosis of breast cancer

Authors: 1QI Jie, 2ZOU Shitao, 2LI Xiaoqing
1 Department of Thyroid Breast Surgery, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou Jiangsu 215001
2 The Core Laboratory of Cancer Center, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou Jiangsu 215001, China

CorrespondingAuthor: LI Xiaoqing Email: lxqzyc@yeah.net

DOI: 10.3978/j.issn.2095-6959.2017.06.023

Abstract

Objective: Our objective is to explore the clinical application value of serum tumor abnormal protein (TAP), carcinoembryonic antigen (CEA) and carbohydrate antigen 153 (CA153) in the early diagnosis of breast cancer. Methods: Forty-five patients with breast cancer were collected as experimental group and 49 normal population as control group. The sensitivity, specificity, accuracy rate and other indicators were compared. Results: In experimental group, the sensitivity of TAP, CEA and CA153 were 80.00%, 8.89% and 6.67% respectively. The specificity of those indicators were 100.00%, 97.96% and 100.00% respectively. The accuracy those indicators were 90.42%, 55.32% and 55.32% respectively. Conclusion: The TAP had more clinical value than CEA and CA153 as an indicator and could be considered as a better screening index in the early diagnosis of breast cancer.

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