文章摘要

MicroRNA与胶质瘤关系的研究进展

作者: 1,2张明, 2,3张金岭, 2,4车峰远
1 山东医学高等专科学校附属医院神经内科，山东 临沂 276004
2 临沂市脑肿瘤功能影像工程技术研究中心，山东 临沂 276004
3 临沂市人民医院肿瘤科，山东 临沂 276004
4 临沂市人民医院神经内科，山东 临沂 276004
通讯: 车峰远 Email: Che1971@126.com
DOI: 10.3978/j.issn.2095-6959.2017.06.037
基金: 临沂市级重点项目, 2016ZK001 山东省医药卫生科技发展项目, 2015WSA13031

摘要

胶质瘤是一种最常见的颅内肿瘤，约占所有颅内肿瘤的50%。MicroRNA是一种长为18~25 nt，进化上高度保守的内源性非编码小分子RNA。实验证据表明microRNA可通过调控其靶标基因参与的信号通路，影响肿瘤的发生和发展，发挥类似于癌基因或抑癌基因的功能。与正常脑组织相比，多种microRNA在许多胶质瘤组织中异常表达，为胶质瘤的诊断和治疗提供了新的策略。
关键词： 微小RNA 胶质瘤 分子标志物

Research progress of microRNA and glioma

Authors: 1,2ZHANG Ming, 2,3ZHANG Jinling, 2,4CHE Fengyuan
1 Department of Neurology, Affiliated Hospital of Shandong Medical College, Linyi Shandong 276004
2 Image Research Center on Brain Tumor of Linyi City, Linyi Shandong 276004
3 Department of Oncology, Linyi People's Hospital, Linyi Shandong 276004
4 Department of Neurology, Linyi People's Hospital, Linyi Shandong 276004, China

CorrespondingAuthor: CHE Fengyuan Email: Che1971@126.com

DOI: 10.3978/j.issn.2095-6959.2017.06.037

Abstract

Glioma is the most common intracranial tumor, accounting for about 50% of all intracranial tumors. MicroRNA is a 18~25 nt, highly evolutionarily conserved endogenous non-coding small RNA. Experimental evidence indicates that microRNAs can play a role in tumorigenesis or tumor suppressor by regulating the signal pathways involved in their target genes, which may influence the genesis and development of tumors. There is growing evidence that a variety of microRNAs are expressed abnormally in many gliomas compared with normal brain tissue, providing a new strategy for the diagnosis and treatment of gliomas.

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