中性粒细胞-淋巴细胞比值和C-反应蛋白在细菌性社区获得性肺炎诊断中的临床价值
| 作者: |
1朱宇敏
1 南京中医药大学附属南京市中西医结合医院呼吸科，南京 210014 |
| 通讯: |
朱宇敏
Email: zhuyumin0501@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2017.06.025 |
摘要
目的：探讨中性粒细胞-淋巴细胞比值(neutrophil-lymphocyte count ratio，NLCR)和CRP在细菌性社区获得性肺炎诊断中的临床价值。方法：采用回顾性病例对照研究方法，分析115例细菌性肺炎、64例非细菌性肺炎和61例健康体检者外周血白细胞总数、中性粒细胞计数、淋巴细胞计数、NLCR和CRP含量，并对检测结果进行统计学分析。结果：细菌性肺炎患者外周血NLCR和CRP水平显著高于非细菌组和健康对照组，差异有统计学意义(P<0.05)。ROC曲线分析显示NLCR和CRP在细菌性肺炎诊断中的曲线下面积分别为0.700和0.794，且对细菌性肺炎具有良好的敏感性和特异性。结论：联合检测外周血NLCR和CRP对细菌性肺炎的诊断具有重要的临床价值。
关键词：
中性粒细胞-淋巴细胞比值
C–反应蛋白
社区获得性肺炎
细菌性肺炎
Clinical value of neutrophil-lymphocyte count ratio and C-reactive protein in the diagnosis of bacterial community-acquired pneumonia
CorrespondingAuthor: ZHU Yumin Email: zhuyumin0501@163.com
DOI: 10.3978/j.issn.2095-6959.2017.06.025
Abstract
Objective: To explore the value of neutrophil-lymphocyte count ratio (NLCR) and CRP in the diagnosis of community-acquired pneumonia. Methods: The NLCR, as well as white blood cell counts, neutrophil count, lymphocyte count and the concentration of CRP were measured in 115 patients with bacterial pneumonia, 64 patients with non-bacterial pneumonia and 61 healthy subjects, and the results were analyzed by statistical methods. Results: In bacterial group, the NLCR and the concentration of CRP were significantly higher than those in non-bacterial group and normal controls (P<0.05). According to the results of receiver operating characteristic curve (ROC) curve analysis in the diagnostic of bacterial pneumonia, the areas of NLCR and CRP under ROC curve are 0.700 and 0.794, respectively, and have good diagnostic sensitivity and specificity. Conclusion: Combined detection of NLCR and CRP in peripheral blood have great significance in the diagnosis of bacterial pneumonia.