237例恶性黑色素瘤临床病理分析
| 作者: |
1陈丽芳,
1朱伟峰,
1陈燕坪,
1许春伟,
1陈刚
1 福建医科大学附属福建省肿瘤医院病理科，福州 350014 |
| 通讯: |
许春伟
Email: xuchunweibbb@163.com 陈刚 Email: naichengang@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2017.06.010 |
| 基金: | 国家临床重点专科建设项目, 2013 |
摘要
目的：探讨237例恶性黑色素瘤(malignant melanoma，MM)的临床病理特点。方法：收集237例不同部位MM病例，复习其临床资料、HE形态，其中128例行免疫组织化学检测。结果：本组109例(45.99%，109/237)根据病史、发病部位、HE形态直接诊断；其余128例(54.01%，128/237)由于形态不典型、黑色素稀少或无色素，做免疫组织化学确诊，其中HMB45阳性率79%(101/128)、melan-A阳性率81%(104/128)、S-100阳性率90%(115/128)。结论：MM的病理形态多样，免疫组织化学检测有助于诊断，其发病机制及临床治疗有待进一步探讨。
关键词：
恶性黑色素瘤
免疫组织化学
临床病理
Clinicopathological analysis of 237 cases of malignant melanoma
CorrespondingAuthor: XU Chunwei Email: xuchunweibbb@163.com
DOI: 10.3978/j.issn.2095-6959.2017.06.010
Abstract
Objective: To investigate the clinicopathological features of 237 cases of malignant melanoma. Methods: A total of 237 cases of malignant melanoma were collected and their clinical data and HE morphology were reviewed, of 128 patients with immunohistochemical detection. Results: One hundred and nine cases (45.99%, 109/237) can be direct diagnosed according to the history, location and HE morphology; the remaining 128 patients (54.01%, 128/237) with immunohistochemical detection because the morphology was not typical and few or no melanin pigment. The positive rate of HMB45, melan-A and S-100 were 79% (101/128), 81% (104/128), and 90% (115/128). Conclusion: Because of the pathological morphological diversity of malignant melanoma, immunohistochemical detection is helpful to diagnosis, its pathogenesis and clinical treatment remains to be further discussed.