Objective: To evaluate the effect of continuous telephone follow-up in patients with myocardial infarction. Methods: A total of 128 patients with myocardial infarction admitted to our hospital from January 2015 to May 2016 were selected. The patients were divided into an observation group and a control group by random number table method, 64 cases in each group. The control group was only discharged health education, and the observation group received a continuous telephone follow-up for 6 months. Results: Before intervention, there were no significant differences in SF-36 scores between the two groups (P>0.05). Six months after the intervention, the quality of life of the observation group increased significantly (P<0.05), but there was no significant change in the control group (P>0.05). Before the intervention, there were no significant differences in the scores of the ESCA scale between the 2 groups (P>0.05). The self-care ability of the observation group increased significantly (P<0.05) 6 months after the intervention, but no significant change in the control group (P>0.05). There was no significant difference in SAS and SDS scores between two groups before intervention (P>0.05). Six months after the intervention, the anxiety and depression of the observation group improved significantly (P<0.05), but there was no significant change in the control group (P>0.05). Conclusion: Continuous telephone follow-up can improve the quality of life and self-care of patients with myocardial infarction and improve their mental health status, which is worthy of clinical recommendation.