Objective: To investigate the effect of combined traditional Chinese and western medicine and aerobic exercise on cancer-related fatigue and anxious and depression in lymphoma patients. Methods: A total of 122 patients diagnosed with lymphoma was enrolled in this research, which was divided into two groups, the intervention group treated with combined traditional Chinese and western medicine and aerobic exercise and the control group treated with usual nursing care. The cancer-related fatigue and anxious and depression was measured by piper cancer-related fatigue scale and the hospital anxiety and depression scale, respectively. Results: The intervention group was significantly better than control group in terms of total fatigue scale, Cognitive emotion scale dimension, sensory dimension, cognitive dimension, affective dimension and Behavioral severity dimension. The scale of anxious and depression of intervention group was significantly lower than control group. Conclusion: The combined traditional Chinese and western medicine and aerobic exercise was much better than usual nursing care in the treatment of cancer-related fatigue and anxious and depression in lymphoma patients.