二甲双胍联合辛伐他汀治疗多囊卵巢综合征的临床疗效
| 作者: |
1娟王,
1阮祥燕,
1金凤羽
1 首都医科大学附属北京妇产医院内分泌科，北京 100020 |
| 通讯: |
娟王
Email: drjuanwang@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2017.05.021 |
| 基金: | 首都卫生发展科研专项基金, 2016-2-2113 |
摘要
目的：观察二甲双胍联合辛伐他汀在多囊卵巢综合征(polycystic ovary syndrome，PCOS)治疗中的临床疗效。方法：收集首都医科大学附属北京妇产医院2014年6月至2016年6月门诊就诊的PCOS患者共120例，随机进入二甲双胍联合辛伐他汀治疗组和二甲双胍治疗组，用药治疗3个月。对两组患者治疗前后的性激素、血糖参数、血脂参数进行检测。结果：两组患者治疗前后相比，性激素、血糖参数、血脂参数均显著改善，差异具有统计学意义(P<0.05)；两组之间相比，联合治疗组疗效显著优于二甲双胍治疗组，差异具有统计学意义(P<0.05)。结论：二甲双胍联合辛伐他汀治疗PCOS的疗效优于二甲双胍单用，对改善患者性激素水平、血糖和血脂指标具有优势。
关键词：
二甲双胍
辛伐他汀
多囊卵巢综合征
临床疗效
性激素
血糖
血脂
Clinical effect of metformin combined with simvastatin in the treatment of polycystic ovary syndrome
CorrespondingAuthor: WANG Juan Email: drjuanwang@163.com
DOI: 10.3978/j.issn.2095-6959.2017.05.021
Abstract
Objective: To observe the clinical effect of metformin combined with simvastatin in the treatment of polycystic ovary syndrome (PCOS). Methods: A total of 120 patients with PCOS from June 2014 to June 2016 were randomly divided into a metformin plus simvastatin group and a metformin group for 3 months. The parameters of sex hormones, blood glucose and blood lipid were measured before and after treatment. Results: Compared with before treatment, the endocrine parameters of the two groups were significantly improved, the differences were statistically significant (P<0.05); the effect in the combined treatment group was significantly better than that in the metformin group, the differences were statistically significant (P<0.05). Conclusion: Metformin combined with simvastatin in the treatment of PCOS is superior to metformin alone in improvment of the efficacy of patients with polycystic ovary syndrome, which have an advantage in improving level of sex hormones, blood glucose, and lipid.