文章摘要

超声波加疤痕止痒软化膏治疗对烧伤瘢痕瘙痒患者康复的效果及预后的影响

作者: 1于天培, 1姜春茹
1 东部战区空军医院康复医学科,南京 210000
通讯: 姜春茹 Email: 276698727@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.10.023

摘要

目的:探究烧伤瘢痕瘙痒患者应用超声波加疤痕止痒软化膏治疗效果以及对预后的影响。方法:选取2016年2月至2018年2月80例在东部战区空军医院治疗烧伤瘢痕后存在瘙痒患者,随机分为对照组和联合组,每组40例。对照组采用疤痕止痒软化膏进行治疗,联合组采用超声波加疤痕止痒软化膏治疗。比较两组治疗前后瘙痒程度、瘙痒评分、疤痕相关因子水平、治疗效果及预后情况。结果:联合组与对照组治疗后瘙痒程度较治疗前显著减轻(Hc=52.771,31.782;P<0.05),治疗后联合组患者瘙痒程度轻于对照组,差异比较具有统计学意义(Hc=4.632,P<0.05);两组患者治疗后瘙痒程度、部位、频率以及睡眠影响评分均明显改善(P<0.05),治疗后联合组患者上述评分较对照组低,差异有统计学意义(P<0.05);两组患者治疗后血清表皮生长因子(epidermal growth factor,EGF)、转化生长因子β1(transforming growth factor,TGF-β1)以及P物质水平较治疗前显著减少(P<0.05),治疗后联合组上述指标水平低于对照组,差异有统计学意义(P<0.05);联合组治疗总有效率高于对照组,差异比较有统计学意义(97.50% vs 80.00%,P<0.05);联合组瘙痒复发率低于对照组,美观满意度高于对照组,差异具有统计学意义(20.00% vs 47.50%,92.50% vs 70.00%,P<0.05)。结论:烧伤瘢痕瘙痒应用超声波加疤痕止痒软化膏治疗瘙痒效果显著,可以明显减少相关因子水平,改善患者预后。
关键词: 超声波;疤痕止痒软化膏;烧伤瘢痕瘙痒;康复效果;预后

Effects of ultrasound and anti-itch scar softening ointment on rehabilitation of patients with burn scar pruritus and their influence on the prognosis

Authors: 1YU Tianpei, 1JIANG Chunru
1 Department of Rehabilitation, Air Force Hospital of the PLA Eastern Theater, Nanjing 210000, China

CorrespondingAuthor: JIANG Chunru Email: 276698727@qq.com

Abstract

Objective: To investigate the effects of ultrasound and anti-itch scar softening ointment in the treatment of burn scar pruritus and the influence on the prognosis. Methods: A total of 80 patients who had pruritus after treatment for burn scars in the hospital between February 2016 and February 2018 were selected as the subjects. They were randomly divided into two groups with 40 patients in each group. Both groups were treated with anti-itch scar softening ointment, and the combined group were additionally treated with ultrasound. The degree of pruritus, pruritus scores and levels of scar related factors before and after the treatment, treatment effects and prognosis of the two groups were compared. Results: After the treatment, the degree of pruritus in both groups was significantly relieved (Hc=52.771, 31.782, P<0.05), and it was milder in the combined group than the control group (Hc=4.632, P<0.05). After the treatment, the degree, location and frequency of pruritus and effect on sleep were significantly improved (P<0.05), and they were better in the combined group than the control group (P<0.05). After treatment, levels of serum epidermal growth factor (epidermal growth factor, EGF), transforming growth factor (transforming growth factor, TGF-β1) and substance P in both groups were decreased significantly (P<0.05), and the levels in combined group were lower than those in the control group (P<0.05). The total response rate and satisfaction rate with appearance of the combined group (97.50% and 92.50%) were higher than those of the control group (80.00% and 70.00%), while the recurrence rate of pruritus (20.00%) was lower than the control group (47.50%, P<0.05). Conclusion: Ultrasound combined with anti-itch scar softening ointment is effective in the treatment of burn scar pruritus. It can significantly reduce the levels of related factors and improve the prognosis of patients.
Keywords: ultrasound; anti-itch scar softening ointment; burn scar pruritus; rehabilitation effect; prognosis