文章摘要

血浆D-二聚体、纤维蛋白原含量、AT-III活性的测定在恶性肿瘤诊断中的临床价值

作者: 1金萍, 1王亚萍, 2孙兵, 1龚芳, 1卢志贤
1 江南大学附属医院检验科,江苏 无锡 214041
2 中国人民解放军63680部队医院检验科,江苏 江阴 214400
通讯: 卢志贤 Email: seed001lzx@163.com
DOI: 10.3978/j.issn.2095-6959.2020.10.005
基金: 江苏省“333”人才资助项目(BRA2019152)。

摘要

目的:检测不同恶性肿瘤患者血浆D-二聚体(D-dimer,D-D)和纤维蛋白原(fibrinogen,Fbg)含量及抗凝血酶III(antithrombin III,AT-III)活性,探讨其对于恶性肿瘤患者诊断的临床价值。方法:由法国STAGO公司的全自动凝血分析仪测定265例恶性肿瘤患者血浆D-D,AT-III活性,Fbg含量并进行比较,同时选择100例健康体检者作为正常对照组。结果:恶性肿瘤患者血浆D-D和Fbg含量升高,与正常对照组比较差异有统计学意义(P<0.05),AT-III活性显著低于正常对照组(P<0.05)。结论:通过检测患者D-D,AT-III活性,Fbg含量有助于恶性肿瘤的辅助诊断,具有临床应用价值。
关键词: 恶性肿瘤;D-二聚体;抗凝血酶III活性;纤维蛋白原含量

Clinical value of plasma D-dimer, fibrinogen content, and AT-III activity in diagnosis of malignant tumor

Authors: 1JIN Ping, 1WANG Yaping, 2SUN Bing, 1GONG Fang, 1LU Zhixian
1 Department of Laboratory, Affiliated Hospital of Jiangnan University, Wuxi Jiangsu 214041, China
2 Department of Laboratory, 63680 Army Hospital, Jiangsu Jiangyin 214400, China

CorrespondingAuthor: LU Zhixian Email: seed001lzx@163.com

Foundation: This work was supported by the ‘333’talent funding project of Jiangsu Province, China (BRA2019152).

Abstract

Objective: To investigate the clinical value of plasma D-dimer, fibrinogen, and antithrombin III activity in patients with malignant tumor. Methods: The densities of plasma D-dimer, antithrombin III activity, fibrinogen were detected in the 265 patients with malignant tumors. And 100 healthy cases were selected as a normal control group. The detecting instrument was Automatic Coagulation Analyzer of STAGO company (France). Results: Compared with the normal control group, the levels of plasma D-dimer and fibrinogen in patients with malignant tumors were significantly increased (P<0.05), antithrombin III activity was significantly lower than that of the normal control group (P<0.05). Conclusion: The detection of D-dimer, antithrombin III activity, and fibrinogen is helpful for the auxiliary diagnosis of malignant tumor.
Keywords: malignant tumor; D-dimmer; antithrombin III activity; fibrinogen