文章摘要

Toll样受体4与肾纤维化的关系研究进展

作者: 1宋 学萍, 1梁 娟, 1王 颖娥, 1黄 强, 1刘 东
1 中国人民解放军联勤保障部队第九四〇医院重症医学科,兰州 730050
通讯: 刘 东 Email: 386748801@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.01.024
基金: 甘肃青年科学基金项目(81600700)。

摘要

肾纤维化是大多数慢性肾脏疾病进展至终末期肾病的基本病理改变,其发病过程受到多种信号通路的调节。肾纤维化过程以持续炎症为特征,包括炎性细胞浸润和细胞因子分泌。Toll样受体4(Toll-like receptor-4,TLR4)信号分子是介导肾脏炎症及纤维化的重要桥梁,可通过核因子-κB(nuclear factor-kappa B,NF-κB)激活炎性因子大量释放而造成肾纤维化。TLR4在肾纤维化中发挥重要作用。
关键词: Toll样受体4;肾纤维化;核因子-κB

Research progress on the relationship between Toll-like receptor 4 and renal fibrosis

Authors: 1SONG Xueping, 1LIANG Juan, 1WANG Ying’e, 1HUANG Qiang, 1LIU Dong
1 Department of Nephrology, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou 730050, China

CorrespondingAuthor:LIU Dong Email: 386748801@qq.com

Foundation: This work was supported by the Gansu Youth Science Fund Project, China (81600700).

Abstract

Renal fibrosis is the basic pathological change of most chronic kidney diseases progression to end-stage renal disease. The pathogenesis is regulated by various signaling pathways. The renal fibrosis process is characterized by persistent inflammation, including inflammatory cell infiltration and cytokine secretion. Toll-like receptor 4 (TLR4) signaling molecule is an important bridge mediating renal inflammation and fibrosis, which can cause renal fibrosis by activating the release of inflammatory factors by nuclear factor-kappa B (NF-κB). TLR4 plays an important role in renal fibrosis.
Keywords: Toll-like receptor4; renal fibrosis; nuclear factor-kappa B