文章摘要

RELMβ 与疾病

作者: 1,2段 旦, 2,3戴 爱国, 2胡 瑞成, 2朱 黎明, 2蒋 永亮, 2孔 春初, 2陈 云荣, 2李 洁
1 南华大学研究生院,湖南 衡阳 421001
2 湖南省人民医院呼吸内科,长沙 410016
3 长沙医学院呼吸疾病研究所,长沙 410219
通讯: 戴 爱国 Email: daiaiguo2003@163.com
DOI: 10.3978/j.issn.2095-6959.2019.02.027
基金: 国家自然科学基金 (81570052)。

摘要

抵抗素样分子β(resistin-like molecule beta,RELMβ)是近年来发现的参与多种慢性疾病的炎症因子,同时又被称为FIZZ2(found in inflammatory zone 2)。由于RELMβ在疾病过程中起不可忽视的作用,国内外对该蛋白的研究越来越多。目前该蛋白在血管生长、平滑肌增殖、气道炎症等方面的作用已有相关研究。本文就RELMβ的结构、调控、生物学功能,重点对RELMβ在肺部疾病和消化道疾病中的作用作一综述。
关键词: 抵抗素样分子β;肺部疾病;消化道疾病

RELMβ and diseases

Authors: 1,2DUAN Dan, 2,3DAI Aiguo, 2HU Ruicheng, 2ZHU Liming, 2JIANG Yongliang, 2KONG Chunchu, 2CHEN Yunrong, 2LI Jie
1 Graduate School, University of South China, Hengyang Hunan 421001, China
2 Department of Respiratory Medicine, Hunan Provincial People’s Hospital, Changsha 410016, China
3 Institute of Respiratory Diseases, Changsha Medical University, Changsha 410219, China

CorrespondingAuthor:DAI Aiguo Email: daiaiguo2003@163.com

Foundation: This work was supported by the National Natural Science Foundation of China (81570052).

Abstract

Resistin-like molecule beta (RELMβ) is an inflammatory factor that has been found in many chronic diseases in recent years and is also known as “found in inflammatory zone 2” (FIZZ2). As the protein plays a crucial role in the diseases, there are more and more articles on the protein family at home and abroad. At present, the effects of this protein on vascular growth, smooth muscle proliferation, airway inflammation have been studied. This review aims to summarize the structure, regulation, biological functions of RELMβ, as well as focus on the effects of RELMβ on the lung diseases and digestive disease.
Keywords: resistin-like molecule β; pulmonary disease; disease of digestive tract