2型糖尿病并发视网膜病变的骨密度分析
| 作者: |
1王超,
1马维青,
1张强,
1刘皆,
1吕芳,
1王国娟,
1胡国平,
1吴德云,
1孙春萍,
2刘杨
1 安徽医科大学第三附属医院内分泌科，合肥 230061 2 安徽医科大学第三附属医院骨密度室，合肥 230061 |
| 通讯: |
王超
Email: wangchaowawa@yeah.net 马维青 Email: maweiqingzr@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.06.025 |
摘要
目的：探讨2型糖尿病患者合并视网膜病变其骨密度的变化。方法：选择2型糖尿病患者111例，按糖尿病视网膜病变分为糖尿病视网膜病变组和糖尿病眼底正常对照组，采用全自动生化检测仪测定甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血尿酸，骨密度采由美国Norland公司XR-36型双能X线骨密度仪测定，分别测定腰椎正位(L2、L3、L4)、左侧股骨颈、大粗隆区、Ward’s三角区的骨密度。结果：1)糖尿病视网膜病变组股骨颈、大粗隆区、Ward’s三角区的骨密度低于对照组，差异有统计学意义(P<0.05)；而在腰椎正位两者的差异无统计学意义(P>0.05)；2)糖尿病患者的骨密度与体重指数、尿酸呈正相关，与年龄、糖尿病病程、甘油三脂、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇呈负相关。结论：2型糖尿病合并视网膜病变其骨密度降低。
关键词：
2型糖尿病
糖尿病视网膜病变
骨密度
Bone mineral density analysis in type 2 diabetes retinopathy
CorrespondingAuthor: WANG Chao Email: wangchaowawa@yeah.net
DOI: 10.3978/j.issn.2095-6959.2015.06.025
Abstract
Objective: To investigate the changes of bone mineral density in patients with type 2 diabetic retinopathy.
Methods: A total of 111 patients with type 2 diabetes were selected. They were divided into two groups, retinopathy group, non- retinopathy group. Triglycerides, total cholesterol, high-density lipoprotein cholesterol, low density lipoprotein cholesterol, blood uric acid was measured by automatic biochemical detector. Bone mineral density was measured by the United States-36 dual-energy X-ray absorptiometry (dexa) which is from Norland XR Company. Asessed the BMD of lumbar vertebrae 1-4 and the left side of the femoral neck, greater trochanter and Ward’s triangle. Results: 1) The femoral neck of diabetic patients with retinopathy, greater trochanter and Ward's triangle compared with diabetic patients with non-retinopathy, the BMD of the former is lower the later, the difference was statistically significant (P<0.05). There was no statistically significant difference in the lumbar spine (P>0.05); 2) The BMD was positively correlated with BMI, uric acid. And negatively correlated with age, duration, blood lipids in type 2 diabetes. Conclusion: In patients with type 2 diabetic retinopathy the bone mineral density is decrease.
Methods: A total of 111 patients with type 2 diabetes were selected. They were divided into two groups, retinopathy group, non- retinopathy group. Triglycerides, total cholesterol, high-density lipoprotein cholesterol, low density lipoprotein cholesterol, blood uric acid was measured by automatic biochemical detector. Bone mineral density was measured by the United States-36 dual-energy X-ray absorptiometry (dexa) which is from Norland XR Company. Asessed the BMD of lumbar vertebrae 1-4 and the left side of the femoral neck, greater trochanter and Ward’s triangle. Results: 1) The femoral neck of diabetic patients with retinopathy, greater trochanter and Ward's triangle compared with diabetic patients with non-retinopathy, the BMD of the former is lower the later, the difference was statistically significant (P<0.05). There was no statistically significant difference in the lumbar spine (P>0.05); 2) The BMD was positively correlated with BMI, uric acid. And negatively correlated with age, duration, blood lipids in type 2 diabetes. Conclusion: In patients with type 2 diabetic retinopathy the bone mineral density is decrease.