20例梭形细胞癌的病理形态及免疫组织化学特征
| 作者: |
1李晶
1 广州金域医学检验中心有限公司实验诊断部病理科，广州 510330 |
| 通讯: |
李晶
Email: sumslij@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2017.01.008 |
摘要
目的：探讨梭形细胞癌的形态学及免疫组织化学特征及鉴别诊断。方法：收集20例梭形细胞癌病例的临床及病理资料，分析其形态学特征及免疫表型特征。结果：20例梭形细胞癌中男性12例，女性8例，平均年龄62.5岁。肿瘤无器官特异性，肿瘤细胞呈梭形，多数病例异型性明显，少数病例细胞温和，异形性不明显。免疫组织化学示肿瘤细胞均表达vimentin；至少表达一种上皮标志物；CK，34βE12，CK5/6，EMA和P63阳性率较高；常表达desmin，calponin，SMA；不表达CD34，S100，HMB-45，myogenin，MyoD1，ALK。结论：梭形细胞癌是一种具有独特形态学和免疫表型的肿瘤。
关键词：
梭形细胞癌
临床病理特征
免疫组织化学
Morphological and immunohistochemical features in 20 cases of spindle cell carcinoma
CorrespondingAuthor: LI Jing Email: sumslij@126.com
DOI: 10.3978/j.issn.2095-6959.2017.01.008
Abstract
Objective: To investigate the morphological and immunohistochemical features and differential diagnosis of spindle cell carcinoma. Methods: The clinical and pathological data of 20 cases of spindle cell carcinoma were collected, and the morphological characteristics and immunohistochemical features were analyzed. Results: Among the 20 cases of spindle cell carcinoma, 12 were male and 8 were female. The mean age was 62.5 years. Tumor cells were fusiform while tumor was not organ specificity, most cases were pleomorphism which is not obvious, a few mild cases of cells. Immunohistochemistry revealed that vimentin was positive in all cases, at least one of epithelial markers was positive. CK, 34βE12, CK5/6, EMA and p63 had higher positive rate. And desmin, calponin, SMA were positive in many cases. CD34, S-100, HMB-45, myogenin, MyoD1, ALK were negative in all cases. Conclusion: Spindle cell carcinoma is a kind of tumor with special morphology and immune phenotype.