Objectives: To investigate the ruminative response levels of chronically critical ill (CCI) patients and to discuss the related influence factors. Methods: General demographic data questionnaire and Ruminative Responses Scale (RRS) were adopted to investigate 97 CCI patients meeting the selection standards from a certain hospital in Foshan City. Results: The total score of ruminative responses of CCI patients was 65.96±16.40; the total score and the scores of various factors were evidently higher than the national norms (P<0.05). As indicated by the multiple linear regression results, length of stay in ICU, assisted ventilation conditions, self-help ability, medical expense burden capacity and social support conditions were the influence factors of the ruminative responses of CCI patients (P<0.05); explaining 36.5% of amount of variability. Conclusion: The ruminative responses of CCI patients are in a relatively high level. The nurses should enhance the effective evaluation on the patients in the practice of treatment. Moreover, they should conduct targeted nursing intervention from different perspectives according to the specific conditions of the patients, correct the negative thinking mode of the patients, and improve their level of adaptation to illness and psychological health.