文章摘要

特异性促炎症消退介质在炎症调控中的研究进展

作者: 1欧唯为, 1肖继, 2陈泉, 1王德明
1 南华大学附属第二医院麻醉科，湖南 衡阳 421001
2 娄底市中心医院麻醉科，湖南 娄底 417000
通讯: 王德明 Email: 395010339@qq.com
DOI: 10.3978/j.issn.2095-6959.2016.11.035
基金: 国家自然科学基金青年基金资助项目, 81301625 湖南省科技厅项目资助, 2013FJ6006

摘要

特异性促炎症消退介质(specialized pro-resolving mediators，SPM)是一种由必需脂肪酸衍生而来的酶类物质，在组织炎症消退过程中发挥抑制炎症反应，促进炎症消退的作用。了解SPM在恢复感染组织中的机制及作用，有利于为SPM应用于宿主定向治疗提供理论依据。为此，本文将对促炎症介质对炎症的内源性调节作用进行综述。
关键词： 特异性促炎症消退介质 炎症 内源性调控

Study progress of specialized pro-resolving mediators in the regulation of inflammation

Authors: 1OU Weiwei, 1XIAO Ji, 2CHEN Quan, 1WANG Deming
1 Department of anesthesiology, The Second Hospital Affiliated to University of South China, Hengyang Hunan 421001
2 Department of anesthesiology, Loudi Central Hospital, Loudi Hunan 417000, China

CorrespondingAuthor: WANG Deming Email: 395010339@qq.com

DOI: 10.3978/j.issn.2095-6959.2016.11.035

Abstract

Specialized pro-resolving mediators (SPMs) are enzymatically derived from essential fatty acids and have important roles in inhibiting the reaction of inflammation, promoting the resolution of tissue inflammation—that is enzymes. To fully understand the mechanism and role of SPMs in the recovery of infected tissues, it is beneficial to provide theoretical basis for SPMs applied to the treatment of the host. Here, we focus primarily on SPMs and their roles in endogenous regulation of inflammation.

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