Objective: To explore the clinicopathological features, pathological diagnosis and differential diagnosis of special types of Wilms’ tumor. Methods: Five cases of special Wilms’ tumor were studied with analysis of clinical data, pathological and immunohistochemical features, and the diagnosis and differential diagnosis were discussed with review of literatures. Results: There were 3 boys and 2 girls with age ranging from 4 months to 2 years old (median 1 year old). The clinical manifestations were abdominal mass, painless gross hematuria, bloating or fever. Tumors located in the left kidney more than right kidney. Microscopic examination showed cysts with different sizes and lined with flat, cubic or hobnail epithelial cells, between them there were Wilms’ tumor components, such as mesenchymal, germ or epithelium in 3 cases of cystic partially differentiated nephroblastoma. The other 2 cases were composed of classical Wilms’ tumor and nephrogenic rests which mean germ and epithelial cells scattered in normal kidney. Conclusion: Cystic partially differentiated nephroblastoma and Wilms’ tumor with nephrogenic rests were rare and special types of Wilms’ tumor. Because of difficulty of diagnosis and differential diagnosis before operation, the pathological diagnosis is the most accurate method and the most reliable accordance for treatment and prognosis.