Objective: To explore the curative effect and satisfaction degree on systematic nursing intervention of patients after percutaneous nephrostomy (PCN) suffered from acute renal obstruction and complicated with renal failure. Methods: 52 patients suffered from acute renal obstruction and complicated with renal failure received treatment in our hospital from Feb 2013 to Dec 2016. All patients were randomly divided into experimental group and control group after PCN. The control group received conventional nursing. The experimental group received conventional nursing as well as systematic nursing intervention. Compared two groups of patients with postoperative renal function and the satisfaction of nursing work, we could evaluate the systematic nursing intervention on whether patients have a positive effect. Results: The concentration of urea nitrogen (BUN), creatinine (Cr) were measured in patients of the experimental group is lower than the patients of the control group in the third and the seventh day, which were both compared respectively with statistical significance (P<0.05). In the third and the seventh day, the degree of satisfaction in the patients of the experimental group were higher than the patients of the control group, which had significant statistical significance, too (P<0.05). Conclusion: PCN in the treatment of acute renal obstruction complicated with renal failure has a remarkable curative effect, and the systematic nursing intervention can promote the effect of the treatment for patients postoperatively.